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Tumors with inherited or somatic deficiencies in HRR genes, such as BRCA1, BRCA2, PALB2, and RAD51, exhibit synthetic lethality to PARPis, including olaparib, rucaparib, niraparib, and talazoparib, which have shown durable efficacy in BRCA-mutant breast, ovarian, and prostate cancers

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Topical diclofenac gel applied directly to the painful area reduces localized inflammation without the systemic downsides of oral NSAIDs

Diagnostic features: May be a sessile broad-based mass or characterized by diffusely thickening of mucosa

Recognizing when you are deficient in glutathione and curbing these mistakes is essential for maintaining optimal health and keeping oxidative stress at bay