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In a randomized clinical trial, tesamorelin reduced visceral adipose tissue and liver fat in HIV-infected patients (Stanley et al., JAMA, 2014), and its Phase 3 program (Falutz et al.) established the visceral-fat effect that underpins its FDA approval
Some patients are naturally less responsive to incretin-based therapies, though this represents a minority of cases
Most practitioners who work with these compounds suggest introducing one peptide at a time to isolate tolerance before combining
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