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Suspected adverse reactions should be reported to the MHRA via the Yellow Card Scheme at yellowcard
It mimics the incretin hormone GLP-1, which stimulates insulin secretion, suppresses glucagon release, and reduces appetite through central nervous system signaling
Retatrutide is a triple receptor agonist that activates GLP-1, GIP, and glucagon receptors simultaneously, whereas semaglutide activates only the GLP-1 receptor and tirzepatide activates both GLP-1 and GIP receptors
Because gastric emptying is delayed, eating too quickly can lead to a rapid build-up of food in the stomach before fullness signals are registered, resulting in nausea or discomfort
Kovacs-Nolan, J., et al
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