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Preclinical findings suggest that TB 500 may regulate cell migration, angiogenesis, and tissue remodeling through modulation of actin polymerization and growth factor-associated signaling pathways
As a result, this reduction often reflects in the skin in the form of dullness, uneven tone, and early signs of aging
The current mainstream mechanism of targeting mitochondria by nanomedicine focuses on the adsorption of positive charges to the mitochondrial membrane
Lancet 376 , 431439 (2010)
177 Mitophagy receptors such as Fun14 domain containing 1 (FUNDC1), BCL2 interacting protein 3 (BNIP3), BCL2 interacting protein 3 like (BNIP3L/NIX), FKBP prolyl isomerase 8 (FKBP8), and ATAD3B can directly interact with LC3 through their LIR (LC3-interacting region) motifs, thereby initiating ubiquitin-independent mitophagy
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