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Ex-vivo experiments: short-term culture of P
Besides being a potential source of more reactive free radicals via Fenton reaction, physiological generation of H 2 O 2 fulfills a second messenger role and can be transported across membranes by aquaporins, a family of proteins that act as peroxiporins (Sies, 2014)
These changes predominantly affected pathways involved in inflammatory responses, cytokine production and macrophage activation
The same phenomenon was observed in the aortic tissues of aging mice after FOXO4-DRI treatment (Figures 6C,D)
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