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4.10 SURMOUNT-1: tirzepatide for weight loss in obese adults In the SURMOUNT-1 trial, 2,539 adults with an average weight of 104.8 kg and an average BMI of 38.0 were treated with weekly doses of tirzepatide (5 mg, 10 mg, 15 mg) or placebo for 72 weeks
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Los efectos secundarios gastrointestinales ms comunes (nuseas, diarrea, vmitos) suelen ser ms intensos durante las primeras semanas de tratamiento o despus de aumentos de dosis
PKA and Epac-2 also activate cyclin D and CREB, leading to beta-cell proliferation, differentiation, and a decrease in endoplasmic reticulum stress response (24)
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