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PLC 2 Phosphatidylinositol-specific phospholipase C gamma 2 (PLC2) has emerged as a significant regulatory enzyme in cellular signaling, primarily through its catalytic role in breaking down membrane-bound phospholipids to produce diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) [157]

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At the same time, J&J has submitted an application to the European Medicines Agency (EMA) requesting approval for a new indication for Imbruvica in adults with previously untreated mantle cell lymphoma (MCL) who are eligible for autologous stem cell transplantation

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TKT and TKTL1 rather than TKTL2 are essential for promoting cell growth and reducing oxidative stress in cancer cells (106, 107)