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DNMTis, including azacitidine and decitabine, are approved for myeloid malignancies and are being actively evaluated in combination with chemotherapy and ICBs in solid tumors to reverse epigenetically mediated drug tolerance
However, semaglutide is contraindicated in individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia type 2 (MEN2)
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In addition to weight loss, both have other potential health benefits, including improved blood sugar control and reduced risk of cardiovascular issues, dementia, and cancer
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