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Kimball and Murlin [2] discovered PG in 1923
Pro tip: Best used under supervision in cutting phases when hunger regulation and energy preservation are key
You then apply them all over your skin at night
Patients on tirzepatide lost an average of 20.2% of their body weight over 72 weeks Patients on semaglutide lost an average of 13.7% of their body weight over the same period 47% more tirzepatide patients achieved 25% or greater body weight loss compared to semaglutide Tirzepatide also produced greater reductions in waist circumference across all dose comparisons A 2024 meta-analysis published in JAMA Internal Medicine analyzing real-world data from over 140,000 patients confirmed the same pattern: tirzepatide produced an average of 4.23 kg more weight loss than semaglutide across all doses and durations studied
After treatment, cell death was evaluated as described in Fig 5
