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This test is performed every 3 to 6 months
In two multicenter studies of over 1,500 patients requiring NSAID therapy, HZT-501 demonstrated a ~55% reduction in the risk of ulcer (determined by endoscopy) compared to ibuprofen alone over 24 weeks (Laine 2012)
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Therefore, several research groups have aimed to develop novel TG-like substrates that can be used in a high-throughput 96-well assay format, does not require the use of radioisotopes, nor complex procedures to separate hydrolyzed from non-hydrolyzed substrate (Figure 5A), LPL enriched HR fractions from BV-2 microglia, but not in HF fractions from BV-2 microglia where LPL expression has been knocked out using CRISPR-Cas9 (Figure 5B), and PHP (Figure 5C)
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