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Inhibition of PPAR leads to serum acylcarnitine accumulation [190], whereas hepatic PPAR activation induced by energy deprivation or fibrates is associated with an increase in the carnitine concentration and a decrease in serum acylcarnitine accumulation [191, 192]

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82 Thus, thioredoxin could be an important therapeutic target for the prevention and treatment of oxidative stress and hypertension

This research peptide may act via the MC4 receptors and downstream of established neuromodulators, including dopaminergic and oxytocinergic signals, possibly integrating their actions within discrete hypothalamic centers