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The simplest way to think about it Wegovy works on 1 pathway (GLP-1) Mounjaro works on 2 pathways (GLP-1 + GIP) Retatrutide (still being studied) works on 3 pathways (GLP-1 + GIP + glucagon) More pathways may mean stronger appetite and metabolic effects, which is why retatrutide is getting so much attention

Storage, Handling, and Safety Precautions Storage and handling requirements for retatrutide are defined solely by the trial sponsor's protocol

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Resources & further reading SURMOUNT-5: Tirzepatide vs