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While the theoretical rationale is sound, no clinical trial has tested this specific combination, and the safety profile of triple-pathway activation through separate compounds is unknown

Wu CX, Zhang SA, Liu MD, He JH

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According to Mankin et al, the rigorousness of the OA destruction was categorized using the histologic standards (Table 2) based on structural variations (scale range 06), cellular variations (scale range 03), damage of safranin O staining (scale range 04) and tidemark integrity (scale range 01) by 3 independent researchers