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The 13-amino acid extension (Met-Phe-Pro-Ala-Met-Pro-Leu-Ser-Ser-Leu-Phe-Val-Asn) does more than add length
Although metformin wasn't developed as a weight-loss drug, research has found that weight loss is a common effect of the medication along with blood glucose regulation
A small study of 8 healthy older adults found that GHRH administration before sleep increased slow-wave sleep duration by 25% and decreased REM sleep latency (Steiger et al., Neuroendocrinology 1992)
Sleep Med Clin
GLP-1 agonists are thought to flip that switch back to the OFF or at minimum, act as a dimmer switch to tone down the intensity of the ON signaling thereby reducing the production of inflammatory cytokines
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