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Patients with diabetic retinopathy, diabetic neuropathy, and both diabetes and hyperlipidemia had a significantly lower total and free carnitine level compared with the diabetic patients without complications or co-morbidities
Reconstitution with bacteriostatic water rather than sterile water for injection allows multi-dose vial use without microbial contamination risk, but introduces benzyl alcohol as a preservative
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In cases of low dietary intake, carnitine deficiency or increased need for energy production, it is important to replenish it
Several mechanistic pathways have been hypothesized to underpin these clinical observations, which involves the influence of GLP-1RA on inflammatory, oxidative stress, and angiogenesis pathways in the atherosclerotic process [69,70,71,72]
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