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In DESTINY-Lung02 trial, grade 3 AEs occurred in 38.6% and 58% of patients with 5.4 and 6.4 mg/kg, respectively
Nature Aging, 4 (12), 1772
Senolytic FOXO4-DRI can inhibit FOXO4 binding by disrupting the p53-FOXO4 interaction and selectively cause apoptosis via p53 nuclear exclusion in senescent cells and aging mouse models, which may be a promising approach for preventing senescence 11
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The peptide is naturally occurring, non-toxic, and effective at very low concentrations
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