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Compared with the rate constants of most bioorthogonal reactions, which fell in the range of 10 1 to 10 3 M 1 s 1 , the dimerization rates of the MSA2 analogues reported herein were at least ten- to a hundred-fold faster, showing a potential benefit of moving beyond the constraints of biorthogonality
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11 Bone marrow suppression is common and potentially affects all cell lines, with megaloblastic anemia being most common
[29] [30] Dimensionality-reduction techniquessuch as Principal Component Analysis (PCA), t-SNE, and UMAPare frequently employed alongside clustering algorithms to visualize peptide libraries and identify clusters with related biological activities
Phase 3 TRIUMPH-4 confirmed 28.7% weight loss at 68 weeks
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