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Melanotan I binds to the melanocortin 1 receptor (MC1R) and its stimulation causes an activation of the melanocytes

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This results in a blockade of IGF-1 beneficial actions [124, 126, 127]

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The effects of IGF-1 on mouse spermatogenesis using an organ culture method [PMID: 28552527] Laboratory literature summary: The effects of IGF-1 on mouse spermatogenesis using an organ culture method

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