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Therefore, GLP-1 should not induce hypoglycemia when administered alone or with other antidiabetic agents that do not cause hypoglycemia, such as metformin (MET), thiazolidinediones (TZDs) and alpha-glucosidase inhibitors (AGIs)

This affects numerous systems in the body including digestion, absorption of nutrients, respiration, blood circulation, elimination of waste from the body and regulation of body temperature

They suppress post-prandial glucagon release, delay stomach emptying, and increase insulin sensitivity

And that pathway has an expiration date

Endothelial nitric oxide synthase in vascular disease: from marvel to menace