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Research suggests that specific variants in FTO gene (rs9939609) are associated with differential medication response patterns
Glutamate toxicity can be reduced by antioxidants, and the psychoactive principle of cannabis, tetrahydrocannabinol (THC), and the non-psychoactive principle cannabidiol (CBD), and other cannabinoids, is found to block glutamate neurotoxicity with a similar potency, and thereby potent antioxidants
there are differences in bioavailability and regulatory concern
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