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The K29R and D77 mutations were introduced to prevent undesirable Ub chain elongation, and the K48R mutation was introduced to restrict the K48 linkage position in the second reaction step
Additionally, improved insulin sensitivity may affect renal sodium handling and fluid balance
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Common side effects for both include nausea, constipation, and digestive discomfort, especially during dose escalation
Dealing with dizziness from Wegovy Dizziness can occur while taking Wegovy and is often linked to nausea, dehydration, or low blood sugar
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