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Int J Mol Sci 15:87138742
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A C20 fatty di-acid moiety attached via a Glu2AEEA linker enables reversible serum albumin binding and extends the circulating half-life to approximately six days, supporting once-weekly research dosing protocols comparable to those used for tirzepatide and semaglutide
This can be attributed to improved metabolic function and a lower demand on the liver to process excess lipids
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