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Molecular mechanism of olaquindox-induced hepatotoxicity and the hepatic protective role of curcumin
The increase in PyroGlu could be due to three key points: (I) the catabolism of GSH through gamma-glutamyl transpeptidase, (II) and/or to a limiting factor in the second step of gamma-glutamylcysteine synthetase (III) or a limiting factor in the following step involving glutathione synthetase
2003 Jan;11(1):23-9
The copper binding is essential
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