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5d), while reducing 47 + regulatory CD4 + T cells in the tdLNs 59 (Extended Data Fig
Dysfunctional adipose tissue promotes increased cardiovascular and diabetes disease risk via multiple pathways including increased free fatty acids (FFA) in the liver, infiltration of visceral fat deposits by proinflammatory macrophages resulting in chronic low-grade inflammation, and reduced buffering capacity for protective lipid storage [7]
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108 Elevated concentrations of these inflammatory cytokines have been detected in the plasma and cerebrospinal fluid of patients with AD, 109 and postmortem analyses revealed an inflammatory milieu within the AD brain, 110 implicating inflammation as a contributory factor in the pathogenesis of dementia
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