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Figure 3 Neddylation of cullin RING ligases is a promising molecular target to restore defective IL-2R signaling in Tregs We recently identified a druggable defect in the IL-2R signaling pathway of Tregs from patients with autoimmune diseases (62)
Results Compared with the earlier period new users, later period new users in both cohorts were older, had more severe CKD, used less intensive type 2 diabetes medication, and had better metabolic control
AOD 9604 has no FDA approval for any human or veterinary use
doi: 10.1007/s11695-012-0802-1 36 ChenYCorsinoLShantavasinkulPCGrantJPortenierDDingLet al
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