The gradually restored gut microbiota not only reduces liver inflammation and oxidative stress but also enhances the intestinal barrier by promoting the expression of zonula ZO-1, Occludin-1, and Mucin-1 in intestinal tissues and ultimately achieves the effect of reducing hepatotoxicity and ALI ( 4 -induced hepatotoxicity and ALI ( Although such medicines targeting gut microbiota dysbiosis have great potential in the prevention and treatment of hepatotoxicity and ALI, there are still some deficiencies and challenges, including the following: 1
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Aihong Gu, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers