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How they interact with metoprolol: Diphenhydramine is a CYP2D6 inhibitor, which can increase the effects of metoprolol, raising the risk of side effects like low blood pressure and a slow heart rate

Wang X, Zhang H, Zhang Q, et al

Eli Lilly, which sells Zepbound and Mounjaro, just released a blockbuster Q2 this morning, beating Wall Street projections and raising its 2025 sales guidance

Not Appropriate for All Injection Systems Certain prefilled pens are not designed to split doses

The peptide's apparent stability across the gastric environment is part of why oral administration is sometimes argued for in this indication