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TLR 5, toll-like receptor 5
The copper coordination chemistry of GHK-Cu enables controlled cellular copper delivery while preventing the formation of reactive oxygen species characteristic of free copper toxicity, with the peptide's binding affinity (log K = 16.1) positioning it perfectly within the physiological copper transport hierarchy to facilitate controlled metal transfer to enzymatic targets including lysyl oxidase (essential for collagen cross-linking) and superoxide dismutase (critical for antioxidant defense)
This study used two experimental systems dermal papilla cell (DPC) cultures and ex vivo human hair follicle organ culture to evaluate AHK-Cus effects on the cellular and structural components of hair growth
