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In Bolivia, the CMS incidence was reported to be between 6% and 8% among the male population of La Paz (3600 m), 54 whereas a hospital study in the same region reported a frequency of 28%, predominantly among patients with respiratory diseases
However, direct GH replacement carries risks associated with supraphysiological dosing
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It is initiated during the ischemia stage due to energy metabolism disorders and further amplified during the reperfusion stage due to a surge in ROS, severely disrupting cellular homeostasis and organ function
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