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Common side effects The most common side effects of Ozempic pill may include: Nausea Vomiting Diarrhea Stomach (abdominal) pain Decreased appetite Diarrhea Constipation Stomach (abdominal) pain Nausea, vomiting, and diarrhea are most common when first starting Ozempic pill and when your dose increases

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The rates are remarkably similar across all three, despite their different mechanisms: Semaglutide: Nausea approximately 18%, diarrhea approximately 12%, vomiting approximately 8% Tirzepatide: Nausea 17-22% (dose dependent), diarrhea 13-16%, vomiting 6-10% Retatrutide: Nausea 16-25% (dose dependent), diarrhea 15-22%, vomiting 8-13% The pattern holds consistently

The FDA has issued public warnings about dosing errors and adverse events involving compounded semaglutide and tirzepatide - with more than 1,700 adverse events linked to compounded semaglutide and tirzepatide combined as of May 21, 2026, according to FDA's published adverse event data