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The decreased sensitivity of cancer cells to these inhibitors may be due to several reasons, including extracellular GSH binding to and inactivating the inhibitors

Those most commonly affected include people over 50 as the ability to absorb B12 from food naturally declines with age as well as vegetarians and vegans, those with pernicious anaemia, anyone who has undergone gastrointestinal surgery, and those living with digestive conditions such as Crohn's disease or coeliac disease

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