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4 Nanoparticles regulate DCs DCs are specialized antigen-presenting cells that can capture the antigens released by tumor cells and present them to T cells in tumor-draining lymph nodes to produce tumor-specific cytotoxic T lymphocytes (CTLs) (97), besides DCs can also stimulate NK cells and B cells to activate humoral immunity (98), therefore, strategies that increase the number of DCs or promote their maturation can enhance anti-tumor immunity