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Sitagliptin In Vitro Assessment of Drug Interactions Sitagliptin is not an inhibitor of CYP isozymes CYP3A4, 2C8, 2C9, 2D6, 1A2, 2C19 or 2B6, and is not an inducer of CYP3A4

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The compound remains detectable in urine for up to 4 days by mass spectrometry methods, despite its short plasma half-life, suggesting tissue distribution and binding may extend its biological effects beyond plasma clearance times