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(2024, CNS Neuroscience & Therapeutics ) confirmed ARA-290 provided neuroprotective effects in a mouse MCAO (middle cerebral artery occlusion) model comparable to full-length EPO, significantly reducing neuronal apoptosis and inflammatory cytokines, confirmed to act via CR without stimulating erythropoiesis Blood-brain barrier (BBB) penetration confirmed in pre-clinical studies
5.1 Possible strategies of One-Two Punch therapy The inaugural investigations delving into the potential of this therapeutic strategy surfaced in the year 2017 [135]
IGF-1 has insulin-like effects that increase glucose uptake into cells
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