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In the NEJM 2023 phase 2 trial, the highest-dose group achieved approximately 24% mean body weight reduction at 48 weeks, exceeding results reported for both semaglutide and tirzepatide in their own trials

In the event of vitamin B12 deficiency, digestive disorders are common (nausea, diarrhoea, constipation)

Stone CA, O'Leary N

Jonathan Rasouli, a neurosurgeon at Northwells Staten Island University Hospital, told The Post

Despite no evidence of this same effect in humans, GLP-1s aren't recommended for people with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome 2 (MEN 2)