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How Semaglutide Changes Your Alcohol Response Many semaglutide users report dramatic changes in their relationship with alcohol: Lower tolerance Effects hit faster and stronger Reduced desire Many simply don't want to drink as much Increased nausea Alcohol can worsen GI side effects Prolonged intoxication Slower stomach emptying keeps alcohol in your system longer Worse hangovers Even small amounts can cause significant next-day symptoms The Science Behind It Semaglutide slows gastric emptying meaning food and drinks stay in your stomach longer

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