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In conclusion, ESSENCE establishes semaglutide as a cornerstone therapy for MASH with F2-F3 fibrosis in metabolically high-risk patients, providing robust histologic improvement, substantial weight loss, and broad cardiometabolic benefit

Step 7: Consider Switching to Tirzepatide If youve maximized your semaglutide dose, optimized lifestyle factors, ruled out medical causes, and youre still stuck, switching to tirzepatide may be the logical next step

Shift it by a day and keep the every-other-day gap intact: days 1, 3, 6 is fine, days 1, 2, 3 is not

Ria Shirsolkar, MD, MS, offers personalized advice on which treatment is right for you at Stone Ridge Wellness & Aesthetics

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