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Reilly, R

Because it can make fibroblasts produce new collagen, thereby promoting metabolism and collagen regeneration, and copper ions act on cells, and are also an important component of multi-enzyme reactions, helping the formation of glucopolyamine to achieve the effect of reducing fine lines

For a broader framework on how SubQ compares to other delivery routes across peptide and antioxidant compounds, this breakdown on oral versus injection delivery gives you the pharmacokinetic context you require to understand this topic on a deeper level

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Other risk factors for B12 deficiency are stress, excessive alcohol use, and smoking