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Important warnings and side effects include: GLP-1 agonist and GLP-1 / GIP agonist drugs like Saxenda (liraglutide), Foundayo (orforglipron) (Wegovy (semaglutide) and Zepbound (tirzepatide) all contain a Boxed Warning for thyroid C-cell tumor cancer

[10] [19] If you have a personal or family history of thyroid cancer, discuss this with your clinician before use

Some patients benefit from prophylactic anti-nausea medication during the first few weeks

The discontinuation rates due to adverse events, which were comparable to placebo, suggest that the transition to oral orforglipron is generally well-tolerated by patients already acclimated to incretin therapy

*Correspondence: Wu Yang, [email protected] Xie, [email protected] This article was submitted to Molecular Signalling and Pathways, a section of the journal Frontiers in Molecular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers