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It is approved as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
In contrast, CHOP, which is itself transcriptionally upregulated by ATF4, acts as a negative feedback regulator
Making it less suited for protocols targeting skin remodeling, where multi-day collagen synthesis signaling matters more than peak plasma levels
To further explore the relationship between ferroptosis and renal fibrosis in vitro, we detected fibrotic markers (fibronectin, -SMA and collagen-1) in TGF--induced HK-2 cells
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