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Semaglutide : Selective GLP-1 receptor agonist that suppresses appetite, delays gastric emptying, and enhances glucose-dependent insulin secretion
Across the SURPASS (type 2 diabetes) and SURMOUNT (body composition management) trial programmes, nausea was reported in approximately 2024% of participants on lower doses and up to 2430% on higher doses
In light of these data, we suggest therapies that target energy metabolism and ROS generation to improve kidney function recovery may need to also target the energy and redox derangements observed in the liver
Additionally, oxidative stress activates MAPKs (mitogen-activated protein kinases) including extracellular signal-regulated kinases, c-Jun N-terminal kinases (JNK), and p38 MAPK, which regulate cell growth, differentiation, and inflammation (90, 91)
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