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4-Hydroxynonenal is involved in the signaling of cell proliferation and apoptosis, as well as regulating gene expression in different cell types (Yang et al., 2001
They differ from enzymatic antioxidants, which are enzymes synthesized endogenously, such as the Superoxide Dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), Thioredoxin, and Glutathione S-Transferase (GST), among others
Dropping back to the previous dose for two to four weeks and then attempting the escalation again often works
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