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Intestinal epithelial sirtuin 1 regulates intestinal inflammation during aging in mice by altering the intestinal microbiota

Interestingly, dual inhibition of TNF- and IL-17 in experimental spondyloarthritis model has been shown to ameliorate local inflammation, joint erosions and new bone formation in spine [204], while the effect of double blockade in bone erosion was more potent than neutralizing TNF- or IL-17 alone [205]

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