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This TME is defined by pervasive infiltrates of tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), cancer-associated fibroblasts (CAFs), and a dense mineralized extracellular matrix (ECM) barrier that collectively exclude or exhaust cytotoxic T cells

Large, greasy, creamy, spicy, or very rich meals may feel like too much during week one, especially if your appetite is already low

You administer it once a week, and that's done

Many people find that an evening injection helps them sleep through the initial onset of side effects, which can peak several hours after administration