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Approved by the FDA under the name Egrifta for HIV-related lipodystrophy, it has demonstrated an increase in IGF-1, a 15.2% reduction in visceral fat, and an improvement in body composition in Phase 3 trials
These developments are consistent with the evolving understanding of the gastrointestinal tract as a key endocrine organ that regulates appetite, glucose homeostasis, energy expenditure, and gastrointestinal motility through a complex network of hormonal signals [20]