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Disulfide bonds remain stable in the extracellular environment but are cleaved in the reductive intracellular milieu, characterized by elevated glutathione levels, leading to liposomal destabilization and subsequent drug release
Perkovic V, Tuttle KR, Rossing P, et al
Glutathione is a powerful antioxidant that occurs naturally within the body and is called the master antioxidant
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Following this, acylcarnitine is transferred to the mitochondrial matrix by CACT, which is located in the inner mitochondrial membrane
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