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As weight loss and diabetes drugs like Ozempic, Wegovy and Mounjaro increase in popularity, more users are learning about the risk of potentially serious gastrointestinal side effects associated with the medications, and are choosing to cut back on their dosages without consulting their doctors
GLP1/E therapy also elicited specific changes in the hypothalamic proteomic profile in PNA mice, upregulating proteins involved in the metabolism of non-coding RNA, signaling of nuclear receptor and estrogen-dependent gene expression and downregulating pathways involved in apoptosis, signaling by insulin receptor and cellular responses to starvation
Dec 2019;47:102208
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This is increasingly recognized as a valid approach for obesity management, similar to how blood pressure or cholesterol medications are used long-term
