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The disconnect between preclinical efficacy and human clinical outcomes remains unexplained and represents a significant limitation for potential therapeutic applications
Patients receiving an antipsychotic should be treated with structured lifestyle modifications to promote weight loss and weight gain prevention
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It supports the nervous system by aiding in the formation of myelin, which protects nerve fibres, and it plays a key role in energy production through its involvement in the breakdown of nutrients into usable energy
[5] In a landmark 2014 study, knocking down NNMT in fat and liver protected mice against diet-induced obesity by increasing cellular energy expenditure, and raised adipose SAM and NAD levels
