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Schernthaner and Schernthaner, 2020), metformin is associated with gastrointestinal side effects in around 20% of patients, including nausea, vomiting, diarrhea, bloating, and occasionally lactic acidosis and vitamin B12 malabsorption

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Additionally, the formation of numerous hydrogen bonds and hydrophobic interactions increases both the structural stability of the molecule and its binding afinity to the target receptor

PMID: 32109374