The primary reason is a process called metabolic adaptation, or adaptive thermogenesis
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Many patients taking GLP-1 agonists have experienced persistent vomiting, intestinal blockages, and other digestive complications that have severely impacted their quality of life and required urgent medical attention and/or repeat hospital visits
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Purpose This review evaluates the clinical efficacy, mechanisms of action, and limitations of GLP-1RAs, such as liraglutide, exenatide, and semaglutide, in the management of psoriasis